Total Synthesis of Carolacton and Demethylcarolactons with Potent Antiviral Activity.
Org Lett
; 26(1): 370-375, 2024 01 12.
Article
em En
| MEDLINE
| ID: mdl-38170945
ABSTRACT
Carolacton, a naturally occurring MTHFD1 inhibitor, exhibits potent inhibitory activity against various RNA viruses including SARS-CoV-2. Herein, we present a concise total synthesis of carolacton, featuring the Krische allylation, Marshall coupling, NHK coupling, and RCM reaction as key elements. Additionally, we have synthesized three simplified carolacton analogues, one of which, namely, 14-demethyl-carolacton, exhibited notable antiviral activity. The present work paves the way for further exploration of the therapeutic potential of carolacton and its analogues.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Macrolídeos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article