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Two rare variants that affect the same amino acid in CFTR have distinct responses to ivacaftor.
Li, Hongyu; Rodrat, Mayuree; Al-Salmani, Majid K; Veselu, Diana-Florentina; Han, Sangwoo T; Raraigh, Karen S; Cutting, Garry R; Sheppard, David N.
Afiliação
  • Li H; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
  • Rodrat M; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
  • Al-Salmani MK; Center of Research and Development for Biomedical Instrumentation, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.
  • Veselu DF; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
  • Han ST; Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khoudh, Muscat, Sultanate of Oman.
  • Raraigh KS; School of Biochemistry, University of Bristol, Bristol, UK.
  • Cutting GR; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Sheppard DN; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Physiol ; 602(2): 333-354, 2024 Jan.
Article em En | MEDLINE | ID: mdl-38186087
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolonas / Fibrose Cística Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolonas / Fibrose Cística Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article