BCMA- or GPRC5D-targeting bispecific antibodies in multiple myeloma: efficacy, safety, and resistance mechanisms.
Blood
; 143(13): 1211-1217, 2024 Mar 28.
Article
em En
| MEDLINE
| ID: mdl-38194680
ABSTRACT
ABSTRACT Bispecific antibodies that engage T cells to target B-cell maturation antigen or G-protein-coupled receptor class C group 5 member D have demonstrated remarkable efficacy in heavily pretreated relapsed or refractory multiple myeloma (MM), leading to the recent accelerated approval of teclistamab, elranatamab, and talquetamab by health agencies. Future challenges, however, remain to define their optimal dosing schedule and duration, sequencing, and integration with established anti-MM therapeutics as well as delineating the biological and clinical mediators of immune escape.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Biespecíficos
/
Neoplasias de Plasmócitos
/
Mieloma Múltiplo
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article