Your browser doesn't support javascript.
loading
Growth and micronutrient status parameters of Nigerian preterm infants consuming preterm formula or breastmilk.
Owolabi, Adedotun Joshua; Ayede, Idowu Adejumoke; Akinrinoye, Olugbenga Oyewumi; Falade, Adegoke Gbadegesin; Ajibola, Gboyega Bosun; Christopher, Ologunore Olufisayo; Arifalo, Gregory Olawole; Abiona, Ayodele Oladejo; Feskens, Edith J M; Melse-Boonstra, Alida; Schaafsma, Anne.
Afiliação
  • Owolabi AJ; Division of Human Nutrition and Health, Wageningen University and Research, P.O. Box 9101, 6700 HB, Wageningen, The Netherlands. adedotunowolabi@gmail.com.
  • Ayede IA; Department of Pediatrics, University College Hospital, Ibadan, Nigeria.
  • Akinrinoye OO; Department of Pediatrics, University College Hospital, Ibadan, Nigeria.
  • Falade AG; Department of Pediatrics, University College Hospital, Ibadan, Nigeria.
  • Ajibola GB; Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Nigeria.
  • Christopher OO; Department of Pediatrics, University College Hospital, Ibadan, Nigeria.
  • Arifalo GO; Department of Family Medicine, Sacred Heart Hospital, Lantoro, Abeokuta, Nigeria.
  • Abiona AO; Department of Pediatrics, Adeoyo Maternity Teaching Hospital, Ibadan, Nigeria.
  • Feskens EJM; Division of Human Nutrition and Health, Wageningen University and Research, P.O. Box 9101, 6700 HB, Wageningen, The Netherlands.
  • Melse-Boonstra A; Division of Human Nutrition and Health, Wageningen University and Research, P.O. Box 9101, 6700 HB, Wageningen, The Netherlands.
  • Schaafsma A; Expert Nutrition Team, FrieslandCampina, Stationsplein, Amersfoort, The Netherlands.
Pediatr Res ; 96(2): 380-387, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38195937
ABSTRACT

BACKGROUND:

Moderate-to-late preterm infants (32-34 weeks GA) have increased risk of neonatal morbidities compared to term infants, however dedicated nutritional guidelines are lacking.

METHODS:

Moderate-to-late preterm infants received a preterm formula (n = 17) or breastmilk (n = 24) from age 2-10 weeks in a non-randomized, open-label observational study. Anthropometric measurements were assessed bi-weekly. Blood concentrations of hemoglobin, ferritin, serum retinol, and 25-hydroxy-vitamin D (25OHD) were analyzed at age 2 and 10 weeks.

RESULT:

Average growth per day was 14.7 g/kg BW/day in formula-fed and 12.8 g/kg BW/day in breastmilk-fed infants but not different from each other. Length and head circumference in both groups were in line with the median reference values of the Fenton growth chart. At 10 weeks of age, hemoglobin tended to be higher in the formula-fed group (10.2 g/dL vs. 9.6 g/dL, p = 0.053). 25OHD increased in formula- and breastmilk-fed infants from 73.8 to 180.9 nmol/L and from 70.7 to 97.6 nmol/L, respectively. Serum retinol only increased in the formula-fed group (0.63 to 1.02 µmol/L, p < 0.001).

CONCLUSION:

Breastfeeding resulted in adequate growth in moderate-late preterm infants but was limiting in some micronutrients. The preterm formula provided adequate micronutrients, but weight gain velocity was higher than the Fenton reference value. IMPACT STATEMENT Unfortified breastmilk resulted in adequate growth in weight, length and head circumference in Nigerian moderate to late preterm infants during an study period of 8 weeks, but status of vitamin D, vitamin A and iron needs to be monitored. The high-energy formula, developed for very preterm infants, resulted in higher growth in body weight in moderate to late preterm infants than the median of the Fenton preterm growth chart. This study supports the necessity of dedicated nutritional guidelines, and regular monitoring of growth and nutritional status of moderate to late preterm infants.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina D / Recém-Nascido Prematuro / Estado Nutricional / Micronutrientes / Fórmulas Infantis / Leite Humano Tipo de estudo: Clinical_trials / Observational_studies Limite: Female / Humans / Infant / Male / Newborn País/Região como assunto: Africa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina D / Recém-Nascido Prematuro / Estado Nutricional / Micronutrientes / Fórmulas Infantis / Leite Humano Tipo de estudo: Clinical_trials / Observational_studies Limite: Female / Humans / Infant / Male / Newborn País/Região como assunto: Africa Idioma: En Ano de publicação: 2024 Tipo de documento: Article