Theta-tACS modulates cerebellar-related motor functions and cerebellar-cortical connectivity.
Clin Neurophysiol
; 158: 159-169, 2024 02.
Article
em En
| MEDLINE
| ID: mdl-38219405
ABSTRACT
OBJECTIVE:
To evaluate the effects of cerebellar transcranial alternating current stimulation (tACS) delivered at cerebellar-resonant frequencies, i.e., theta (θ) and gamma (γ), on upper limb motor performance and cerebellum-primary motor cortex (M1) connectivity, as assessed by cerebellar-brain inhibition (CBI), in healthy subjects.METHODS:
Participants underwent cerebellar-tACS while performing three cerebellar-dependent motor tasks (i) rhythmic finger-tapping, (ii) arm reaching-to-grasp ('grasping') and (iii) arm reaching-to-point ('pointing') an object. Also, we evaluated possible changes in CBI during cerebellar-tACS.RESULTS:
θ-tACS decreased movement regularity during the tapping task and increased the duration of the pointing task compared to sham- and γ-tACS. Additionally, θ-tACS increased the CBI effectiveness (greater inhibition). The effect of θ-tACS on movement rhythm correlated with CBI changes and less tapping regularity corresponded to greater CBI.CONCLUSIONS:
Cerebellar-tACS delivered at the θ frequency modulates cerebellar-related motor behavior and this effect is, at least in part, mediated by changes in the cerebellar inhibitory output onto M1. The effects of θ-tACS may be due to the modulation of cerebellar neurons that resonate to the θ rhythm.SIGNIFICANCE:
These findings contribute to a better understanding of the physiological mechanisms of motor control and provide new evidence on cerebellar non-invasive brain stimulation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estimulação Transcraniana por Corrente Contínua
/
Córtex Motor
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article