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Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter protein.
Nakamura, Mariko; Yoshimi, Akira; Tokura, Tatsuya; Kimura, Hiroyuki; Kishi, Shinichi; Miyauchi, Tomoya; Iwamoto, Kunihiro; Ito, Mikiko; Sato-Boku, Aiji; Mouri, Akihiro; Nabeshima, Toshitaka; Ozaki, Norio; Noda, Yukihiro.
Afiliação
  • Nakamura M; Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, Nagoya, Japan.
  • Yoshimi A; Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, Nagoya, Japan.
  • Tokura T; Clinical OMICs and Translation Research Center, Meijo University, Nagoya, Japan.
  • Kimura H; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Kishi S; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Miyauchi T; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Iwamoto K; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Ito M; Department of Psychiatry, KACHI Memorial Hospital, Toyohashi, Japan.
  • Sato-Boku A; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Mouri A; Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi Gakuin University, Nagoya, Japan.
  • Nabeshima T; Department of Anesthesiology, School of Dentistry, Aichi Gakuin University, Nagoya Japan.
  • Ozaki N; Department of Regulatory Science for Evaluation & Development of Pharmaceuticals and Devices, Graduate School of Health Science, Fujita Health University, Aichi, Japan.
  • Noda Y; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Japan.
Pain ; 165(5): 1177-1186, 2024 May 01.
Article em En | MEDLINE | ID: mdl-38227563
ABSTRACT
ABSTRACT Chronic orofacial pain (COP) is relieved by duloxetine (DLX) and frequently causes depressive symptoms. The aim of this study was to confirm effects of DLX on pain and depressive symptoms, and to associate with their effectiveness in platelet serotonin transporter (SERT) expression, which is a target molecule of DLX and plasma serotonin concentration in COP patients with depressive symptoms. We assessed for the severity of pain and depressive symptoms using the Visual Analog Scale (VAS) and 17-item Hamilton Depression Rating Scale (HDRS), respectively. Chronic orofacial pain patients were classified into 2 groups based on their HDRS before DLX-treatment COP patients with (COP-D) and without (COP-ND) depressive symptoms. We found that the VAS and HDRS scores of both groups were significantly decreased after DLX treatment compared with those before DLX treatment. Upregulation of total SERT and downregulation of ubiquitinated SERT were observed before DLX treatment in both groups compared with healthy controls. After DLX treatment, there were no differences in total SERT of both groups and in ubiquitinated SERT of COP-D patients compared with healthy controls; whereas, ubiquitinated SERT of COP-ND patients remained downregulated. There were positive correlations between changes of serotonin concentrations and of VAS or HDRS scores in only COP-D patients. Our findings indicate that DLX improves not only pain but also comorbid depressive symptoms of COP-D patients. Duloxetine also reduces platelet SERT through upregulation of ubiquitinated SERT. As the result, decrease of plasma serotonin concentrations may be related to the efficacy of DLX in relieving pain and depression in COP patients.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas da Membrana Plasmática de Transporte de Serotonina / Dor Crônica Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas da Membrana Plasmática de Transporte de Serotonina / Dor Crônica Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article