Aging, Causes, and Rejuvenation of Hematopoietic Stem Cells.

Chen, Zhiyang; Ju, Zhenyu; Sun, Yan

Chen, Zhiyang; Ju, Zhenyu; Sun, Yan.

Afiliação

Chen Z; Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, China.
Ju Z; Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, China.
Sun Y; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. sunyan@gdph.org.cn.

Adv Exp Med Biol ; 1442: 201-210, 2023.

Article em En | MEDLINE | ID: mdl-38228966

ABSTRACT

ABSTRACT

Hematopoietic stem cells (HSCs) undergo an age-related functional decline, which leads to a disruption of the blood system and contributes to the development of aging-associated hematopoietic diseases and malignancies. In this section, we provide a summary of the key hallmarks associated with HSC aging. We also examine the causal factors that contribute to HSC aging and emphasize potential approaches to mitigate HSC aging and age-related hematopoietic disorders.

Assuntos

Doenças Hematológicas; Rejuvenescimento; Humanos; Envelhecimento; Células-Tronco Hematopoéticas/patologia

Palavras-chave

Aging; HSC; Niche; Therapeutic strategies

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rejuvenescimento / Doenças Hematológicas Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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