Fibrosis in IBD: from pathogenesis to therapeutic targets.
Gut
; 73(5): 854-866, 2024 04 05.
Article
em En
| MEDLINE
| ID: mdl-38233198
ABSTRACT
BACKGROUND:
Intestinal fibrosis resulting in stricture formation and obstruction in Crohn's disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is among the largest unmet needs in inflammatory bowel disease (IBD). Fibrosis is caused by a multifactorial and complex process involving immune and non-immune cells, their soluble mediators and exposure to luminal contents, such as microbiota and environmental factors. To date, no antifibrotic therapy is available. Some progress has been made in creating consensus definitions and measurements to quantify stricture morphology for clinical practice and trials, but approaches to determine the degree of fibrosis within a stricture are still lacking.OBJECTIVE:
We herein describe the current state of stricture pathogenesis, measuring tools and clinical trial endpoints development.DESIGN:
Data presented and discussed in this review derive from the past and recent literature and the authors' own research and experience. RESULTS ANDCONCLUSIONS:
Significant progress has been made in better understanding the pathogenesis of fibrosis, but additional studies and preclinical developments are needed to define specific therapeutic targets.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
/
Colite Ulcerativa
/
Doença de Crohn
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article