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Flexible, scalable, high channel count stereo-electrode for recording in the human brain.
Lee, Keundong; Paulk, Angelique C; Ro, Yun Goo; Cleary, Daniel R; Tonsfeldt, Karen J; Kfir, Yoav; Pezaris, John S; Tchoe, Youngbin; Lee, Jihwan; Bourhis, Andrew M; Vatsyayan, Ritwik; Martin, Joel R; Russman, Samantha M; Yang, Jimmy C; Baohan, Amy; Richardson, R Mark; Williams, Ziv M; Fried, Shelley I; Hoi Sang, U; Raslan, Ahmed M; Ben-Haim, Sharona; Halgren, Eric; Cash, Sydney S; Dayeh, Shadi A.
Afiliação
  • Lee K; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
  • Paulk AC; Department of Neurology, Harvard Medical School, Boston, MA, 02114, USA.
  • Ro YG; Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Cleary DR; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
  • Tonsfeldt KJ; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
  • Kfir Y; Department of Neurological Surgery, University of California San Diego, La Jolla, CA, 92093, USA.
  • Pezaris JS; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
  • Tchoe Y; Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
  • Lee J; Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
  • Bourhis AM; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Vatsyayan R; Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
  • Martin JR; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Russman SM; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
  • Yang JC; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
  • Baohan A; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
  • Richardson RM; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
  • Williams ZM; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
  • Fried SI; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
  • Hoi Sang U; Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
  • Raslan AM; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Ben-Haim S; Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
  • Halgren E; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Cash SS; Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
  • Dayeh SA; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
Nat Commun ; 15(1): 218, 2024 Jan 17.
Article em En | MEDLINE | ID: mdl-38233418
ABSTRACT
Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents an advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Neurônios Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Neurônios Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article