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Genetic Analysis of H5N1 High-Pathogenicity Avian Influenza Virus following a Mass Mortality Event in Wild Geese on the Solway Firth.
Ross, Craig S; Byrne, Alexander M P; Mahmood, Sahar; Thomas, Saumya; Reid, Scott; Freath, Lorna; Griffin, Larry R; Falchieri, Marco; Holmes, Paul; Goldsmith, Nick; Shaw, Jessica M; MacGugan, Alastair; Aegerter, James; Hansen, Rowena; Brown, Ian H; Banyard, Ashley C.
Afiliação
  • Ross CS; Virology Department, Animal and Plant Health Agency (APHA), Addlestone KT15 3NB, UK.
  • Byrne AMP; Virology Department, Animal and Plant Health Agency (APHA), Addlestone KT15 3NB, UK.
  • Mahmood S; Virology Department, Animal and Plant Health Agency (APHA), Addlestone KT15 3NB, UK.
  • Thomas S; Virology Department, Animal and Plant Health Agency (APHA), Addlestone KT15 3NB, UK.
  • Reid S; Virology Department, Animal and Plant Health Agency (APHA), Addlestone KT15 3NB, UK.
  • Freath L; Animal Health and Welfare Advice, Animal and Plant Health Agency (APHA), Addlestone KT15 3NB, UK.
  • Griffin LR; ECO-LG Ltd., Crooks House, Mabie, Dumfries DG2 8EY, UK.
  • Falchieri M; Virology Department, Animal and Plant Health Agency (APHA), Addlestone KT15 3NB, UK.
  • Holmes P; APHA Diseases of Wildlife Scheme, Shrewsbury Veterinary Investigation Centre, Shrewsbury SY1 4HD, UK.
  • Goldsmith N; NatureScot, Great Glen House, Inverness IV3 8NW, UK.
  • Shaw JM; NatureScot, Great Glen House, Inverness IV3 8NW, UK.
  • MacGugan A; NatureScot, Great Glen House, Inverness IV3 8NW, UK.
  • Aegerter J; National Wildlife Management Centre, Animal and Plant Health Agency (APHA), York YO41 1LZ, UK.
  • Hansen R; Virology Department, Animal and Plant Health Agency (APHA), Addlestone KT15 3NB, UK.
  • Brown IH; Animal Health and Welfare Advice, Animal and Plant Health Agency (APHA), Addlestone KT15 3NB, UK.
  • Banyard AC; Virology Department, Animal and Plant Health Agency (APHA), Addlestone KT15 3NB, UK.
Pathogens ; 13(1)2024 Jan 17.
Article em En | MEDLINE | ID: mdl-38251390
ABSTRACT
The United Kingdom (UK) and Europe have seen successive outbreaks of H5N1 clade 2.3.4.4b high-pathogenicity avian influenza virus (HPAIV) since 2020 peaking in the autumn/winter periods. During the 2021/22 season, a mass die-off event of Svalbard Barnacle Geese (Branta leucopsis) was observed on the Solway Firth, a body of water on the west coast border between England and Scotland. This area is used annually by Barnacle Geese to over-winter, before returning to Svalbard to breed. Following initial identification of HPAIV in a Barnacle Goose on 8 November 2021, up to 32% of the total Barnacle Goose population may have succumbed to disease by the end of March 2022, along with other wild bird species in the area. Potential adaptation of the HPAIV to the Barnacle Goose population within this event was evaluated. Whole-genome sequencing of thirty-three HPAIV isolates from wild bird species demonstrated that there had been two distinct incursions of the virus, but the two viruses had remained genetically stable within the population, whilst viruses from infected wild birds were closely related to those from poultry cases occurring in the same region. Analysis of sera from the following year demonstrated that a high percentage (76%) of returning birds had developed antibodies to H5 AIV. This study demonstrates genetic stability of this strain of HPAIV in wild Anseriformes, and that, at the population scale, whilst there is a significant impact on survival, a high proportion of birds recover following infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article