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Comparative pharmacokinetic evaluation of glimepiride orodispersable and conventional tablets in rabbits.
Ur Rahman, Altaf; Nasir, Fazli; Ali Khattak, Muzna; Hidayatullah, Talaya; Pervez, Sadia; Rabqa Zainab, Syeda; Tahir Ali, Arbab; Gohar, Shazma; E Maryam, Gul; Almalki, Waleed H.
Afiliação
  • Ur Rahman A; Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
  • Nasir F; Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
  • Ali Khattak M; Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
  • Hidayatullah T; Department of Pharmacy, CECOS University Peshawar, Peshawar, Pakistan.
  • Pervez S; Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
  • Rabqa Zainab S; Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
  • Tahir Ali A; Department of Pharmacy, City University Peshawar, Peshawar, Pakistan.
  • Gohar S; Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
  • E Maryam G; Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
  • Almalki WH; Department of Pharmacy, Qurtuba University Peshawar, Peshawar, Pakistan.
Drug Dev Ind Pharm ; 50(2): 173-180, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38265062
ABSTRACT

OBJECTIVES:

Glimepiride Orodispersable Tablets (ODT) were prepared with the goal to have rapid onset of action and higher bioavailability with ease administration to individuals with swallowing difficulty to ameliorate patient compliance.

SIGNIFICANCE:

Glimepiride is a contemporary hypoglycemic medication that belongs to the family of sulfonylurea derivatives. It is used in type 2 diabetes mellitus. Compliance adherence remains one of the limitations with the conventional drug delivery system especially in pediatric, geriatric, psychiatric, and traveling patients, for such population ODT provides a good alternate dosage form compared with Commercial Tablets.

METHOD:

The Comparative in vivo pharmacokinetic parameters of the prepared ODT and conventional tablets (CT) were evaluated using an animal model. The plasma concentration of Glimepiride after oral administration of a single dose was determined at predetermined time intervals with HPLC. The pharmacokinetic parameters were calculated using PK Solutions 2.0 from Summit PK® software.

RESULTS:

The Cmax obtained with ODT (22.08 µg/ml) was significantly (p = 0.006) high, a lower tmax of 3.0 hr was achieved with the orodispersable formulation of the drug. The ODT showed 104.34% relative bioavailability as compared to CT and left shift of tmax as well.

CONCLUSION:

As per findings of the in vivo investigation, the Glimepiride ODT would be beneficial in terms of patient compliance, quick onset of action, and increased bioavailability.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Tipo de estudo: Prognostic_studies Limite: Aged / Animals / Child / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Tipo de estudo: Prognostic_studies Limite: Aged / Animals / Child / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article