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Teclistamab: Mechanism of action, clinical, and translational science.
Guo, Yue; Quijano Cardé, Natalia A; Kang, Lijuan; Verona, Raluca; Banerjee, Arnob; Kobos, Rachel; Chastain, Katherine; Uhlar, Clarissa; Pillarisetti, Kodandaram; Doyle, Margaret; Smit, Jennifer; Haddish-Berhane, Nahor; Ouellet, Daniele.
Afiliação
  • Guo Y; Janssen Research & Development, Spring House, Pennsylvania, USA.
  • Quijano Cardé NA; Janssen Research & Development, Spring House, Pennsylvania, USA.
  • Kang L; Janssen Research & Development, Spring House, Pennsylvania, USA.
  • Verona R; Janssen Research & Development, Spring House, Pennsylvania, USA.
  • Banerjee A; Janssen Research & Development, Spring House, Pennsylvania, USA.
  • Kobos R; Janssen Research & Development, Spring House, Pennsylvania, USA.
  • Chastain K; Janssen Research & Development, Spring House, Pennsylvania, USA.
  • Uhlar C; Janssen Research & Development, Spring House, Pennsylvania, USA.
  • Pillarisetti K; Janssen Research & Development, Spring House, Pennsylvania, USA.
  • Doyle M; Janssen Sciences Ireland, Dublin, Ireland.
  • Smit J; Janssen Research & Development, Spring House, Pennsylvania, USA.
  • Haddish-Berhane N; Janssen Research & Development, Spring House, Pennsylvania, USA.
  • Ouellet D; Janssen Research & Development, Spring House, Pennsylvania, USA.
Clin Transl Sci ; 17(1): e13717, 2024 01.
Article em En | MEDLINE | ID: mdl-38266057
ABSTRACT
Multiple myeloma (MM) remains incurable despite improvements in treatment options. B-cell maturation antigen (BCMA) is predominantly expressed in B-lineage cells and represents a promising new target for MM. Teclistamab (TECVAYLITM ) is the first T-cell redirecting bispecific antibody approved for patients with MM. Targeting both CD3 receptor complex on T cells and BCMA on myeloma cells, teclistamab leads to T-cell activation and subsequent lysis of BCMA+ cells. The recommended dose of teclistamab is 1.5 mg/kg subcutaneous weekly after two step-up doses of 0.06 and 0.3 mg/kg, which was selected after review of safety, efficacy, pharmacokinetic, and pharmacodynamic data. Exposure-response analyses of efficacy and safety data were also used to confirm the teclistamab dose. Teclistamab resulted in a high rate of deep and durable responses (63% overall response, 45.5% complete response or better, with 22 months median duration of response) in patients with triple-exposed relapsed/refractory MM. Common adverse reactions included cytokine release syndrome, hematologic abnormalities, and infections. Teclistamab is currently being investigated as monotherapy as well as combination therapy across different MM indications.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Biespecíficos / Mieloma Múltiplo / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Biespecíficos / Mieloma Múltiplo / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article