Case report and systematic review of cerebellar vermis alterations in psychosis.
Int Clin Psychopharmacol
; 39(4): 223-231, 2024 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-38266159
ABSTRACT
INTRODUCTION:
Cerebellar alterations, including both volumetric changes in the cerebellar vermis and dysfunctions of the corticocerebellar connections, have been documented in psychotic disorders. Starting from the clinical observation of a bipolar patient with cerebellar hypoplasia, the purpose of this review is to summarize the data in the literature about the association between hypoplasia of the cerebellar vermis and psychotic disorders [schizophrenia (SCZ) and bipolar disorder (BD)].METHODS:
A bibliographic search on PubMed has been conducted, and 18 articles were finally included in the review five used patients with BD, 12 patients with SCZ and one subject at psychotic risk.RESULTS:
For SCZ patients and subjects at psychotic risk, the results of most of the reviewed studies seem to suggest a gray matter volume reduction coupled with an increase in white matter volumes in the cerebellar vermis, compared to healthy controls. Instead, the results of the studies on BD patients are more heterogeneous with evidence showing a reduction, no difference or even an increase in cerebellar vermis volume compared to healthy controls.CONCLUSIONS:
From the results of the reviewed studies, a possible correlation emerged between cerebellar vermis hypoplasia and psychotic disorders, especially SCZ, ultimately supporting the hypothesis of psychotic disorders as neurodevelopmental disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Esquizofrenia
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Transtorno Bipolar
/
Vermis Cerebelar
Tipo de estudo:
Systematic_reviews
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article