Oxidative DNA damage: Induction by fructose, in vitro, and its enhancement by hydrogen peroxide.
Mutat Res Genet Toxicol Environ Mutagen
; 893: 503719, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38272630
ABSTRACT
Sucrose and high-fructose corn syrup comprise nearly equal amounts of glucose and fructose. With the use of high-fructose corn syrup in the food industry, consumption of fructose, which may be a tumor promoter, has increased dramatically. We examined fructose-induced oxidative DNA damage in the presence of Cu(II), with or without the addition of H2O2. With isolated DNA, fructose induced Cu(II)-mediated DNA damage, including formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), to a greater extent than did glucose, and H2O2 enhanced the damage. In cultured human cells, 8-oxodG formation increased significantly following treatment with fructose and the H2O2-generating enzyme glucose oxidase. Fructose may play an important role in oxidative DNA damage, suggesting a possible mechanism for involvement of fructose in carcinogenesis.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desoxiguanosina
/
Peróxido de Hidrogênio
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article