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Topical trametinib for epidermal and sebaceous nevi in a child with Schimmelpenning-Feuerstein-Mims syndrome.
Haller, Courtney N; Leszczynska, Maria A; Brichta, Lars; Maier, Esther; Riddington, Ian M; Choate, Keith A; Levy, Moise L.
Afiliação
  • Haller CN; Department of Internal Medicine, Division of Dermatology, Dell Medical School, University of Texas, Austin, Texas, USA.
  • Leszczynska MA; Department of Dermatology, Baylor Scott and White, Temple, Texas, USA.
  • Brichta L; Chemistry Rx Compounding and Specialty Pharmacy, Folcroft, Pennsylvania, USA.
  • Maier E; Drug Dynamics Institute, College of Pharmacy, The University of Texas, Austin, Texas, USA.
  • Riddington IM; Department of Chemistry, The University of Texas, Austin, Texas, USA.
  • Choate KA; Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Levy ML; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
Pediatr Dermatol ; 41(3): 523-525, 2024.
Article em En | MEDLINE | ID: mdl-38273779
ABSTRACT
We present the case of a 20-month-old girl with Schimmelpenning-Feuerstein-Mims (SFM) syndrome with extensive head, neck, and torso skin involvement successfully managed with topical trametinib. Trametinib interferes downstream of KRAS and HRAS in the MAPK signaling pathway, of which KRAS was implicated in our child's pathogenic variant. Although other dermatologic conditions have shown benefit from oral trametinib, its topical use has not been well reported. Our patient showed benefit from the use of twice-daily topical trametinib, applied to the epidermal and sebaceous nevi over a 16-month period, leading to decreased pruritus and thinning of the plaques.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Pirimidinonas / Neoplasias Cutâneas Limite: Female / Humans / Infant Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Pirimidinonas / Neoplasias Cutâneas Limite: Female / Humans / Infant Idioma: En Ano de publicação: 2024 Tipo de documento: Article