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Potential Biomarkers for the Earlier Diagnosis of Kidney and Liver Damage in Acute Intermittent Porphyria.
Storjord, Elin; Wahlin, Staffan; Karlsen, Bård Ove; Hardersen, Randolf I; Dickey, Amy K; Ludviksen, Judith K; Brekke, Ole-Lars.
Afiliação
  • Storjord E; Department of Laboratory Medicine, Nordland Hospital Trust, 8092 Bodø, Norway.
  • Wahlin S; Hepatology Division, Department of Upper GI Diseases, Porphyria Centre Sweden, Karolinska Institute and Karolinska University Hospital, 14186 Stockholm, Sweden.
  • Karlsen BO; Department of Laboratory Medicine, Nordland Hospital Trust, 8092 Bodø, Norway.
  • Hardersen RI; Research Laboratory, Nordland Hospital Trust, 8092 Bodø, Norway.
  • Dickey AK; Department of Nephrology, Nordland Hospital Trust, 8092 Bodø, Norway.
  • Ludviksen JK; Department of Clinical Medicine, UiT-The Arctic University of Norway, 9019 Tromsø, Norway.
  • Brekke OL; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Life (Basel) ; 14(1)2023 Dec 21.
Article em En | MEDLINE | ID: mdl-38276268
ABSTRACT
Acute intermittent porphyria (AIP) is an inherited metabolic disorder associated with complications including kidney failure and hepatocellular carcinoma, probably caused by elevations in the porphyrin precursors porphobilinogen (PBG) and delta-aminolevulinic acid (ALA). This study explored differences in modern biomarkers for renal and hepatic damage between AIP patients and controls. Urine PBG testing, kidney injury panels, and liver injury panels, including both routine and modern biomarkers, were performed on plasma and urine samples from AIP cases and matched controls (50 and 48 matched pairs, respectively). Regarding the participants' plasma, the AIP cases had elevated kidney injury marker-1 (KIM-1, p = 0.0002), fatty acid-binding protein-1 (FABP-1, p = 0.04), and α-glutathione S-transferase (α-GST, p = 0.001) compared to the matched controls. The AIP cases with high PBG had increased FABP-1 levels in their plasma and urine compared to those with low PBG. In the AIP cases, KIM-1 correlated positively with PBG, CXCL10, CCL2, and TCC, and the liver marker α-GST correlated positively with IL-13, CCL2, and CCL4 (all p < 0.05). In conclusion, KIM-1, FABP-1, and α-GST could represent potential early indicators of renal and hepatic damage in AIP, demonstrating associations with porphyrin precursors and inflammatory markers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article