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Working Memory Training Responsiveness in Parkinson's Disease Is Not Determined by Cortical Thickness or White Matter Lesions.
Giehl, Kathrin; Theis, Hendrik; Ophey, Anja; Hammes, Jochen; Reker, Paul; Eggers, Carsten; Fink, Gereon R; Kalbe, Elke; van Eimeren, Thilo.
Afiliação
  • Giehl K; Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Multimodal Neuroimaging Group, Cologne, Germany.
  • Theis H; Research Center Jülich, Institute for Neuroscience and Medicine (INM-2), Jülich, Germany.
  • Ophey A; Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Multimodal Neuroimaging Group, Cologne, Germany.
  • Hammes J; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Reker P; Department of Medical Psychology, Faculty of Medicine and University Hospital Cologne, Neuropsychology and Gender Studies and Center for Neuropsychological Diagnostics and Intervention (CeNDI), University of Cologne, Cologne, Germany.
  • Eggers C; Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Multimodal Neuroimaging Group, Cologne, Germany.
  • Fink GR; Nuklearmedizin, Radiologische Allianz, Hamburg, Germany.
  • Kalbe E; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • van Eimeren T; Department of Neurology, Knappschaftskrankenhaus Bottrop, Bottrop, Germany.
J Parkinsons Dis ; 14(2): 347-351, 2024.
Article em En | MEDLINE | ID: mdl-38277302
ABSTRACT
Patients with Parkinson's disease are highly vulnerable for cognitive decline. Thus, early intervention by means of working memory training (WMT) may be effective for the preservation of cognition. However, the influence of structural brain properties, i.e., cortical thickness and volume of white matter lesions on training responsiveness have not been studied. Here, behavioral and neuroimaging data of 46 patients with Parkinson's disease, 21 of whom engaged in home-based, computerized adaptive WMT, was analyzed. While cortical thickness and white matter lesions volume were associated with cognitive performance at baseline, these structural brain properties do not seem to determine WMT responsiveness.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Disfunção Cognitiva / Substância Branca Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Disfunção Cognitiva / Substância Branca Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article