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Gynaecological follow-up for women of reproductive age with multiple sclerosis: The GYNESEP study.
Renaud, Juliette; Buissonnière, Pauline; Dulau, Cécile; Deloire, Mathilde; Hontarrede, Florian; Montcuquet, Alexis; Chansel-Debordeaux, Lucie; Hocké, Claude; Ouallet, Jean-Christophe; Ruet, Aurélie; Bernard, Valérie.
Afiliação
  • Renaud J; Department of Gynecology and Reproductive Medicine, CHU de Bordeaux, Bordeaux F-33000, France.
  • Buissonnière P; Department of Neurology, CHU de Bordeaux, Bordeaux F-33000, France.
  • Dulau C; Department of Neurology, CHU de Bordeaux, Bordeaux F-33000, France.
  • Deloire M; Department of Neurology, CHU de Bordeaux, Bordeaux F-33000, France.
  • Hontarrede F; Department of Neurology, CHU de Bordeaux, Bordeaux F-33000, France.
  • Montcuquet A; Department of Neurology, CHU de Bordeaux, Bordeaux F-33000, France.
  • Chansel-Debordeaux L; Department of Reproductive Biology-CECOS, CHU de Bordeaux, Bordeaux F- 33000, France; Bordeaux Institute of Oncology-BRIC-BioGo Team, INSERM U1312, University of Bordeaux, Bordeaux F-33000, France.
  • Hocké C; Department of Gynecology and Reproductive Medicine, CHU de Bordeaux, Bordeaux F-33000, France.
  • Ouallet JC; Department of Neurology, CHU de Bordeaux, Bordeaux F-33000, France.
  • Ruet A; Department of Neurology, CHU de Bordeaux, Bordeaux F-33000, France; Neurocentre Magendie, INSERM U1215, University Bordeaux, Bordeaux F-33000, France.
  • Bernard V; Department of Gynecology and Reproductive Medicine, CHU de Bordeaux, Bordeaux F-33000, France; Bordeaux Institute of Oncology-BRIC-BioGo Team, INSERM U1312, University of Bordeaux, Bordeaux F-33000, France. Electronic address: valerie.bernard@chu-bordeaux.fr.
Mult Scler Relat Disord ; 83: 105448, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38277979
ABSTRACT

BACKGROUND:

The gynaecological care of women with Multiple Sclerosis has received little attention; most reports focussed on pregnancy or sexuality. The objective of the present study was to evaluate if gynaecological follow-up for women of reproductive age with Multiple Sclerosis was adequate.

METHODS:

We performed a cross-sectional study on a large cohort of women with Multiple Sclerosis aged 18-40 years. All participants completed online questionnaires on general health status, gynaecological follow-up, and sexuality. Expanded Disability Status Scale (EDSS) scores were extracted from medical records. The study was registered in clinicaltrials.gov with the number NCT05248438, and in the European database ID-RCB with the number 2021-A02912-39.

RESULTS:

Of the 192 patients who completed questionnaires, 157 (82.2%) reported gynaecological follow-up. Of the 155 patients on immunosuppressive treatments, only 31 (20%) underwent annual cervical screening. Of the 140 patients who met the French papillomavirus vaccination age recommendations, only 50 (35.7%) were vaccinated. A total of 128 (66.7%) patients used contraception. However, 16 (8.3%) patients reported unplanned pregnancies since the time of diagnosis.

CONCLUSION:

Women with Multiple Sclerosis require more information on reproductive health and prevention of cancer. Better contraceptive advice would reduce the number of unplanned pregnancies and avoid foetal exposure to potentially teratogenic treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Infecções por Papillomavirus / Vacinas contra Papillomavirus / Esclerose Múltipla Tipo de estudo: Guideline / Observational_studies Limite: Female / Humans / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Infecções por Papillomavirus / Vacinas contra Papillomavirus / Esclerose Múltipla Tipo de estudo: Guideline / Observational_studies Limite: Female / Humans / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article