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The Impact of the Mediterranean Diet and Lifestyle Intervention on Lipoprotein Subclass Profiles among Metabolic Syndrome Patients: Findings of a Randomized Controlled Trial.
Candás-Estébanez, Beatriz; Fernández-Cidón, Bárbara; Corbella, Emili; Tebé, Cristian; Fanlo-Maresma, Marta; Esteve-Luque, Virginia; Salas-Salvadó, Jordi; Fitó, Montserrat; Riera-Mestre, Antoni; Ros, Emilio; Pintó, Xavier.
Afiliação
  • Candás-Estébanez B; Clinical Laboratory, Bellvitge University Hospital, 08907 L'Hospitalet de Llobregat, Spain.
  • Fernández-Cidón B; Clinical Laboratory, SCIAS-Barcelona Hospital, 08036 Barcelona, Spain.
  • Corbella E; Clinical Laboratory, Bellvitge University Hospital, 08907 L'Hospitalet de Llobregat, Spain.
  • Tebé C; Department of Biochemistry, Molecular Biology and Biomedicine, Autonomous University of Barcelona (UAB), 08193 Barcelona, Spain.
  • Fanlo-Maresma M; Lipids and Vascular Risk Unit, Internal Medicine Department, Bellvitge University Hospital, 08907 L'Hospitalet de Llobregat, Spain.
  • Esteve-Luque V; Bellvitge Biomedical Research Institute (IDIBELL), 08907 L'Hospitalet de Llobregat, Spain.
  • Salas-Salvadó J; Center for Biomedical Research in Obesity and Nutrition Physiopathology Network (CIBEROBN), Carlos III Health Institute, 28029 Madrid, Spain.
  • Fitó M; Bellvitge Biomedical Research Institute (IDIBELL), 08907 L'Hospitalet de Llobregat, Spain.
  • Riera-Mestre A; Lipids and Vascular Risk Unit, Internal Medicine Department, Bellvitge University Hospital, 08907 L'Hospitalet de Llobregat, Spain.
  • Ros E; Bellvitge Biomedical Research Institute (IDIBELL), 08907 L'Hospitalet de Llobregat, Spain.
  • Pintó X; Center for Biomedical Research in Obesity and Nutrition Physiopathology Network (CIBEROBN), Carlos III Health Institute, 28029 Madrid, Spain.
Int J Mol Sci ; 25(2)2024 Jan 22.
Article em En | MEDLINE | ID: mdl-38279337
ABSTRACT
Metabolic syndrome (MetS) is associated with alterations of lipoprotein structure and function that can be characterized with advanced lipoprotein testing (ADLT). The effect of the Mediterranean diet (MedDiet) and weight loss on the lipoprotein subclass profile has been scarcely studied. Within the PREDIMED-Plus randomized controlled trial, a sub-study conducted at Bellvitge Hospital recruiting center evaluated the effects of a weight loss program based on an energy-reduced MedDiet (er-MedDiet) and physical activity (PA) promotion (intervention group) compared with energy-unrestricted MedDiet recommendations (control group) on ADLT-assessed lipoprotein subclasses. 202 patients with MetS (n = 107, intervention; n = 95, control) were included. Lipid profiles were determined, and ADLT was performed at baseline, 6, and 12 months. Linear mixed models were used to assess the effects of intervention on lipoprotein profiles. Compared to the control diet, at 12 months, the er-MedDiet+PA resulted in a significant additional 4.2 kg of body weight loss, a decrease in body mass index by 1.4 kg/m2, reduction in waist circumference by 2.2 cm, decreased triglycerides, LDL-cholesterol and non-HDL-cholesterol, and increased HDL-cholesterol. In er-MedDiet+PA participants, ADLT revealed a decrease in small dense-LDL-cholesterol (sd-LDL-C), intermediate-density lipoproteins, VLDL-triglyceride, and HDL-Triglyceride, and an increase in large LDL and large VLDL particles. In conclusion, compared to an ad libitum MedDiet (control group), er-MedDiet+PA decreased plasma triglycerides and the triglyceride content in HDL and VLDL particles, decreased sd-LDL-C, and increased large LDL particles, indicating beneficial changes against cardiovascular disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Metabólica / Dieta Mediterrânea Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Metabólica / Dieta Mediterrânea Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article