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Recent advances in infectious disease research using cryo-electron tomography.
Asarnow, Daniel; Becker, Vada A; Bobe, Daija; Dubbledam, Charlie; Johnston, Jake D; Kopylov, Mykhailo; Lavoie, Nathalie R; Li, Qiuye; Mattingly, Jacob M; Mendez, Joshua H; Paraan, Mohammadreza; Turner, Jack; Upadhye, Viraj; Walsh, Richard M; Gupta, Meghna; Eng, Edward T.
Afiliação
  • Asarnow D; Department of Biochemistry, University of Washington, Seattle, WA, United States.
  • Becker VA; Department of Medicinal Chemistry, University of Washington, Seattle, WA, United States.
  • Bobe D; Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.
  • Dubbledam C; Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.
  • Johnston JD; Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.
  • Kopylov M; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, United States.
  • Lavoie NR; Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.
  • Li Q; Department of Molecular Biology and Microbiology, School of Medicine, Tufts University, Boston, MA, United States.
  • Mattingly JM; Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
  • Mendez JH; Department of Chemistry, College of Arts and Sciences, Emory University, Atlanta, GA, United States.
  • Paraan M; Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.
  • Turner J; Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.
  • Upadhye V; European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom.
  • Walsh RM; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
  • Gupta M; Harvard Cryo-Electron Microscopy Center for Structural Biology and Harvard Medical School, Boston, MA, United States.
  • Eng ET; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, United States.
Front Mol Biosci ; 10: 1296941, 2023.
Article em En | MEDLINE | ID: mdl-38288336
ABSTRACT
With the increasing spread of infectious diseases worldwide, there is an urgent need for novel strategies to combat them. Cryogenic sample electron microscopy (cryo-EM) techniques, particularly electron tomography (cryo-ET), have revolutionized the field of infectious disease research by enabling multiscale observation of biological structures in a near-native state. This review highlights the recent advances in infectious disease research using cryo-ET and discusses the potential of this structural biology technique to help discover mechanisms of infection in native environments and guiding in the right direction for future drug discovery.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article