Impact of Biologics and Small-Molecule Agents on Postoperative Complications in IBD: A Systematic Review.
Dis Colon Rectum
; 67(S1): S11-S25, 2024 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-38294838
ABSTRACT
BACKGROUND:
Patients with IBD may require colectomy for severe disease unresponsive or refractory to pharmacological therapy. The question of the impact of biologic use on postoperative complications is a topic of active investigation.OBJECTIVE:
A systematic literature review was performed to describe the current state of knowledge of the impact of perioperative biologic and tofacitinib use on postoperative complications in patients with IBD. DATA SOURCES PubMed and Cochrane databases were searched. STUDY SELECTION Studies between January 2000 and January 2023, in any language, were searched, followed by a snowball search identifying further studies in accordance with Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Articles regarding pediatric or endoscopic management were excluded.INTERVENTIONS:
Preoperative or perioperative exposure to biologics in IBD was included. MAIN OUTCOMEMEASURES:
Infectious and noninfectious complications, including anastomotic leaks, surgical site infections, urinary tract infections, pneumonia, sepsis, septic shock, postoperative length of stay, readmission, and reoperation, were the main outcomes measured.RESULTS:
A total of 28 studies were included for analysis in this review, including 7 meta-analyses or systematic reviews and 5 randomized studies. Snowball search identified 11 additional studies providing topical information. Overall, tumor necrosis factor inhibitors likely do not increase the risk of postoperative adverse outcomes, while data on other biologics and small-molecule agents are emerging.LIMITATIONS:
This is a qualitative review including all study types. The varied nature of study types precludes quantitative comparison.CONCLUSIONS:
Although steroids increase postoperative infectious and noninfectious complications, tumor necrosis factor inhibitors do not appear to increase postoperative infectious and noninfectious complications. There is a need for further perioperative data for other agents. See video from symposium .
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
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Produtos Biológicos
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Doenças Inflamatórias Intestinais
Tipo de estudo:
Clinical_trials
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Guideline
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Prognostic_studies
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Qualitative_research
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article