NMR techniques for investigating antimicrobial peptides in model membranes and bacterial cells.
Methods
; 224: 10-20, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38295893
ABSTRACT
AMPs are short, mainly cationic membrane-active peptides found in all living organism. They perform diverse roles including signaling and acting as a line of defense against bacterial infections. AMPs have been extensively investigated as templates to facilitate the development of novel antimicrobial therapeutics. Understanding the interplay between these membrane-active peptides and the lipid membranes is considered to be a significant step in elucidating the specific mechanism of action of AMPs against prokaryotic and eukaryotic cells to aid the development of new therapeutics. In this review, we have provided a brief overview of various NMR techniques commonly used for studying AMP structure and AMP-membrane interactions in model membranes and whole cells.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Catiônicos Antimicrobianos
/
Peptídeos Antimicrobianos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article