[Progress on microneedle drug delivery systems for the treatment of corneal diseases].
Zhonghua Yan Ke Za Zhi
; 60(2): 186-192, 2024 Feb 11.
Article
em Zh
| MEDLINE
| ID: mdl-38296325
ABSTRACT
Corneal diseases are prevalent eye conditions in China, and the lack of effective treatment in the short term can lead to blindness. However, delivering drugs to the cornea safely and effectively poses a significant challenge due to the presence of ocular barriers and clearance mechanisms. Conventional drug delivery methods exhibit low bioavailability, making it difficult to achieve therapeutic effects. Microneedles, with their ability to penetrate ocular surface barriers effectively, offer a low-invasive and highly promising drug delivery technology. This article introduces the main delivery barriers on the ocular surface, classifies microneedles, and highlights the latest developments in the treatment of corneal diseases. Finally, the potential challenges of applying microneedle delivery systems to the ocular surface are analyzed, aiming to provide insights for the clinical application of microneedles in corneal diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Doenças da Córnea
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article