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First experimental demonstration of real-time neutron capture discrimination in helium and carbon ion therapy.
Kielly, Marissa; Caracciolo, Anita; Chacon, Andrew; Vohradsky, James; Di Vita, Davide; Hamato, Akram; Tashima, Hideaki; Franklin, Daniel R; Yamaya, Taiga; Rosenfeld, Anatoly; Carminati, Marco; Fiorini, Carlo; Guatelli, Susanna; Safavi-Naeini, Mitra.
Afiliação
  • Kielly M; Australian Nuclear Science and Technology Organisation (ANSTO), Lucas Heights, Australia.
  • Caracciolo A; Centre for Medical Radiation Physics, University of Wollongong, Wollongong, Australia.
  • Chacon A; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.
  • Vohradsky J; Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Milano, Milan, Italy.
  • Di Vita D; Australian Nuclear Science and Technology Organisation (ANSTO), Lucas Heights, Australia.
  • Hamato A; Centre for Medical Radiation Physics, University of Wollongong, Wollongong, Australia.
  • Tashima H; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.
  • Franklin DR; Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Milano, Milan, Italy.
  • Yamaya T; Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum Science and Technology (QST), Inage-ku, Chiba, Japan.
  • Rosenfeld A; Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum Science and Technology (QST), Inage-ku, Chiba, Japan.
  • Carminati M; School of Electrical and Data Engineering, University of Technology Sydney, Sydney, Australia.
  • Fiorini C; Imaging Physics Group, Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum Science and Technology (QST), Inage-ku, Chiba, Japan.
  • Guatelli S; Centre for Medical Radiation Physics, University of Wollongong, Wollongong, Australia.
  • Safavi-Naeini M; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.
Sci Rep ; 14(1): 2601, 2024 Jan 31.
Article em En | MEDLINE | ID: mdl-38297114
ABSTRACT
This work provides the first experimental proof of an increased neutron capture photon signal following the introduction of boron to a PMMA phantom during helium and carbon ion therapies in Neutron Capture Enhanced Particle Therapy (NCEPT). NCEPT leverages [Formula see text]B neutron capture, leading to the emission of detectable 478 keV photons. Experiments were performed at the Heavy Ion Medical Accelerator in Chiba, Japan, with two Poly(methyl methacrylate) (PMMA) targets, one bearing a boron insert. The BeNEdiCTE gamma-ray detector measured an increase in the 478 keV signal of 45 ± 7% and 26 ± 2% for carbon and helium ion irradiation, respectively. Our Geant4 Monte Carlo simulation model, developed to investigate photon origins, found less than 30% of detected photons originated from the insert, while boron in the detector's circuit boards contributed over 65%. Further, the model investigated detector sensitivity, establishing its capability to record a 10% increase in 478 keV photon detection at a target [Formula see text]B concentration of 500 ppm using spectral windowing alone, and 25% when combined with temporal windowing. The linear response extended to concentrations up to 20,000 ppm. The increase in the signal in all evaluated cases confirm the potential of the proposed detector design for neutron capture quantification in NCEPT.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2024 Tipo de documento: Article