Your browser doesn't support javascript.
loading
A neonatal piglet model reveals interactions between nasal microbiota and influenza A virus pathogenesis.
Yuan, Fangfeng; Yang, Lufan; Hsiao, Shih-Hsuan; Herndon, Nicole L; Gaulke, Christopher A; Fang, Ying.
Afiliação
  • Yuan F; Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, IL, 61802, USA.
  • Yang L; Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, IL, 61802, USA.
  • Hsiao SH; Veterinary Diagnostic Laboratory, Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61802, USA.
  • Herndon NL; Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61802, USA.
  • Gaulke CA; Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, IL, 61802, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, IL, 61802, USA; Personalized Nutrition Initiative, University of Illinois a
  • Fang Y; Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, IL, 61802, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, IL, 61802, USA. Electronic address: yingf@illinois.edu.
Virology ; 592: 109996, 2024 04.
Article em En | MEDLINE | ID: mdl-38301448
ABSTRACT
While vaccination and therapeutics for prevention/treatment of influenza are available, new strategies are needed to combat influenza disease in susceptible populations, particularly young children and newborns. Host associated microbiota play an important role in modulating the virulence of numerous pathogens, including the influenza A virus. In this study, we examined microbiome-influenza interactions in a neonatal piglet model system. The nasal microbiome of newborn piglets was longitudinally sampled before and after intranasal infection with recombinant viruses expressing hemagglutinins (HAs) derived from distinct zoonotic H1 subtypes. We found that viruses expressing different parental HAs manifested unique patterns of pathogenicity, and varied impacts on microbial community diversity. Despite these virus specific differences, a consistent microbial signature of viral infection was detected. Our results indicate that influenza A virus infection associates with the restructuring of nasal microbiome and such shifts in microbial diversity may contribute to outcomes of viral infection in neonatal piglets.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Infecções por Orthomyxoviridae / Influenza Humana / Microbiota Tipo de estudo: Etiology_studies Limite: Animals / Child / Child, preschool / Humans / Newborn Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Infecções por Orthomyxoviridae / Influenza Humana / Microbiota Tipo de estudo: Etiology_studies Limite: Animals / Child / Child, preschool / Humans / Newborn Idioma: En Ano de publicação: 2024 Tipo de documento: Article