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Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058.
Kimura, So-Ichiro; Watanabe, Yoshihiro; Mikasa, Yudai; Miyano, Rei; Tokiwa, Toshiyuki; Nonaka, Kenichi; Nakashima, Takuji; Noguchi, Yoshihiko; Hirose, Tomoyasu; Sunazuka, Toshiaki; Hokari, Rei; Ishiyama, Aki; Iwatsuki, Masato.
Afiliação
  • Kimura SI; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Watanabe Y; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Mikasa Y; Omura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Miyano R; School of Science, Kitasato University, 1-15-1, Kitazato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan.
  • Tokiwa T; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Nonaka K; Omura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Nakashima T; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Noguchi Y; Omura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Hirose T; Omura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Sunazuka T; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Hokari R; Omura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Ishiyama A; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Iwatsuki M; Omura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
J Antibiot (Tokyo) ; 77(4): 206-213, 2024 04.
Article em En | MEDLINE | ID: mdl-38302743
ABSTRACT
Two new pramanicin analogs, named virgaricins C (1) and D (2), were discovered by physicochemical screening from a static cultured material of Apiospora sp. FKI-8058. Their structures were elucidated by MS and NMR analyses and chemical derivatization. Compounds 1 and 2 showed moderate antimalarial activity and cytotoxicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lactamas / Antimaláricos Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lactamas / Antimaláricos Idioma: En Ano de publicação: 2024 Tipo de documento: Article