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Fatigue predicts quality of life after leucine-rich glioma-inactivated 1-antibody encephalitis.
Binks, Sophie N M; Veldsman, Michele; Handel, Adam E; Jacob, Saiju; Maddison, Paul; Coebergh, Jan; Michael, Sophia; Ramanathan, Sudarshini; Easton, Ava; Nissen, Mette Scheller; Leite, Maria Isabel; Okai, David; Blaabjerg, Morten; Husain, Masud; Irani, Sarosh R.
Afiliação
  • Binks SNM; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Oxford, UK.
  • Veldsman M; Department of Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Handel AE; Department of Experimental Psychology, University of Oxford, Oxford, UK.
  • Jacob S; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Oxford, UK.
  • Maddison P; Department of Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Coebergh J; Department of Neurology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Michael S; Department of Neurology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.
  • Ramanathan S; St Peter's Hospital, Ashford and St Peter's NHS Hospitals Foundation Trust, Chertsey, UK.
  • Easton A; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Oxford, UK.
  • Nissen MS; Department of Neurology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Leite MI; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Oxford, UK.
  • Okai D; Translational Neuroimmunology Group, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
  • Blaabjerg M; Department of Neurology, Concord Hospital, Sydney, New South Wales, Australia.
  • Husain M; The Encephalitis Society, 32 Castlegate, Malton, North Yorkshire, YO17 7DT, UK.
  • Irani SR; Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK.
Ann Clin Transl Neurol ; 11(4): 1053-1058, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38303486
ABSTRACT
Patient-reported quality-of-life (QoL) and carer impacts are not reported after leucine-rich glioma-inactivated 1-antibody encephalitis (LGI1-Ab-E). From 60 patients, 85% (51 out of 60) showed one abnormal score across QoL assessments and 11 multimodal validated questionnaires. Compared to the premorbid state, QoL significantly deteriorated (p < 0.001) and, at a median of 41 months, fatigue was its most important predictor (p = 0.025). In total, 51% (26 out of 51) of carers reported significant burden. An abbreviated five-item battery explained most variance in QoL. Wide-ranging impacts post-LGI1-Ab-E include decreased QoL and high caregiver strain. We identify a rapid method to capture QoL in routine clinic or clinical trial settings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalite / Glioma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalite / Glioma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article