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Reference Values for Water-Specific T1 of the Liver at 3 T: T2*-Compensation and the Confounding Effects of Fat.
Thompson, Richard B; Sherrington, Rachel; Beaulieu, Christian; Kirkham, Amy; Paterson, David I; Seres, Peter; Grenier, Justin.
Afiliação
  • Thompson RB; Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.
  • Sherrington R; Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
  • Beaulieu C; Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.
  • Kirkham A; Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.
  • Paterson DI; Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
  • Seres P; Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, Ontario, Canada.
  • Grenier J; Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
J Magn Reson Imaging ; 60(5): 2063-2075, 2024 Nov.
Article em En | MEDLINE | ID: mdl-38305588
ABSTRACT

BACKGROUND:

T1 mapping of the liver is confounded by the presence of fat. Multiparametric T1 mapping combines fat-water separation with T1-weighting to enable imaging of water-specific T1 (T1Water), proton density fat fraction (PDFF), and T2* values. However, normative T1Water values in the liver and its dependence on age/sex is unknown.

PURPOSE:

Determine normative values for T1Water in the liver with comparison to MOLLI and evaluate a T2*-compensation approach to reduce T1 variability. STUDY TYPE Prospective observational; phantoms. POPULATIONS One hundred twenty-four controls (56 male, 18-75 years), 50 patients at-risk for liver disease (18 male, 30-76 years). FIELD STRENGTH/SEQUENCE 2.89 T; Saturation-recovery chemical-shift encoded T1 Mapping (SR-CSE); MOLLI. ASSESSMENT SR-CSE provided T1Water measurements, PDFF and T2* values in the liver across three slices in 6 seconds. These were compared with MOLLI T1 values. A new T2*-compensation approach to reduce T1 variability was evaluated test/re-test reproducibility. STATISTICAL TESTS Linear regression, ANCOVA, t-test, Bland and Altman, intraclass correlation coefficient (ICC). P < 0.05 was considered statistically significant.

RESULTS:

Liver T1 values were significantly higher in healthy females (F) than males (M) for both SR-CSE (F-973 ± 78 msec, M-930 ± 72 msec) and MOLLI (F-802 ± 55 msec, M-759 ± 69 msec). T1 values were negatively correlated with age, with similar sex- and age-dependencies observed in T2*. The T2*-compensation model reduced the variability of T1 values by half and removed sex- and age-differences (SR-CSE F-946 ± 36 msec, M-941 ± 43 msec; MOLLI F-775 ± 35 msec, M-770 ± 35 msec). At-risk participants had elevated PDFF and T1 values, which became more distinct from the healthy cohort after T2*-compensation. MOLLI systematically underestimated liver T1 values by ~170 msec with an additional positive T1-bias from fat content (~11 msec/1% in PDFF). Reproducibility ICC values were ≥0.96 for all parameters. DATA

CONCLUSION:

Liver T1Water values were lower in males and decreased with age, as observed for SR-CSE and MOLLI acquisitions. MOLLI underestimated liver T1 with an additional large positive fat-modulated T1 bias. T2*-compensation removed sex- and age-dependence in liver T1, reduced the range of healthy values and increased T1 group differences between healthy and at-risk groups. EVIDENCE LEVEL 2 TECHNICAL EFFICACY Stage 1.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Água / Fígado Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Água / Fígado Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article