A closer look at ligand specificity for cellular activation of NOD2 with synthetic muramyl dipeptide analogues.
Chem Commun (Camb)
; 60(16): 2212-2215, 2024 Feb 20.
Article
em En
| MEDLINE
| ID: mdl-38305731
ABSTRACT
To further understand the specificity of muramyl dipeptide (MDP) sensing by NOD2, we evaluated the compatibility of synthetic MDP analogues for cellular uptake and NAGK phosphorylation, the pre-requisite steps of intracellular NOD2 activation. Our results revealed that these two prior steps do not confer ligand stereoselectivity; yet NAGK strictly discriminates against the disaccharide NOD2 agonists for phosphorylation in vitro, despite it being indispensable for the cellular NOD2-stimulating effects of these analogues, implying potential glycosidase cleavage as a novel intermediate step for cellular activation of NOD2.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acetilmuramil-Alanil-Isoglutamina
/
Proteína Adaptadora de Sinalização NOD2
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article