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Expanded Access to Fluoroformamidines via a Modular Synthetic Pathway.
Vogel, James A; Miller, Kirya F; Shin, Eunjeong; Krussman, Jenna M; Melvin, Patrick R.
Afiliação
  • Vogel JA; Department of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania 19010, United States.
  • Miller KF; Department of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania 19010, United States.
  • Shin E; Department of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania 19010, United States.
  • Krussman JM; Department of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania 19010, United States.
Org Lett ; 26(6): 1277-1281, 2024 Feb 16.
Article em En | MEDLINE | ID: mdl-38323858
ABSTRACT
Fluoroformamidines are an underutilized and understudied functional group despite combining two of the most highly prized elements in drug

design:

nitrogen and fluorine. We report a practical and modular synthesis of fluoroformamidines via the rearrangement of in situ-generated amidoximes. High yields in just 60 s at room temperature highlight the efficiency of this protocol. Furthermore, fluoroformamidines proved to be useful intermediates in the synthesis of diverse ureas and carbamimidates.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Ano de publicação: 2024 Tipo de documento: Article