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Ascorbic acid prevents stress-induced hypercoagulability in overweight and obese individuals.
Rocha, Helena N M; Velasco, Larissa L; Batista, Gabriel M S; Storch, Amanda S; Garcia, Vinicius P; Teixeira, Gabriel F; Mentzinger, Juliana; da Nóbrega, Antonio C L; Rocha, Natália G.
Afiliação
  • Rocha HNM; Laboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Rua Alameda Barros Terra, Sala 110, São Domingos, Niterói, RJ, 24.020-150, Brazil.
  • Velasco LL; Laboratory of Integrative Cardiometabology, Department of Physiology and Pharmacology, Fluminense Federal University, Rua Alameda Barros Terra, Sala 110, São Domingos, Niterói, Rio de Janeiro, Brazil.
  • Batista GMS; National Institute of Science and Technology (INCT) - Physical (In)Activity and Exercise, National Council for Scientific and Technological Development (CNPq), Rua Alameda Barros Terra, Sala 110, São Domingos, Niterói, Rio de Janeiro, Brazil.
  • Storch AS; Laboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Rua Alameda Barros Terra, Sala 110, São Domingos, Niterói, RJ, 24.020-150, Brazil.
  • Garcia VP; Laboratory of Integrative Cardiometabology, Department of Physiology and Pharmacology, Fluminense Federal University, Rua Alameda Barros Terra, Sala 110, São Domingos, Niterói, Rio de Janeiro, Brazil.
  • Teixeira GF; Laboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Rua Alameda Barros Terra, Sala 110, São Domingos, Niterói, RJ, 24.020-150, Brazil.
  • Mentzinger J; Laboratory of Integrative Cardiometabology, Department of Physiology and Pharmacology, Fluminense Federal University, Rua Alameda Barros Terra, Sala 110, São Domingos, Niterói, Rio de Janeiro, Brazil.
  • da Nóbrega ACL; Laboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Rua Alameda Barros Terra, Sala 110, São Domingos, Niterói, RJ, 24.020-150, Brazil.
  • Rocha NG; Laboratory of Integrative Cardiometabology, Department of Physiology and Pharmacology, Fluminense Federal University, Rua Alameda Barros Terra, Sala 110, São Domingos, Niterói, Rio de Janeiro, Brazil.
Sci Rep ; 14(1): 3122, 2024 02 07.
Article em En | MEDLINE | ID: mdl-38326408
ABSTRACT
Ascorbic acid (AA) may contribute to restoring hemostatic balance after mental stress (MS) in overweight/obese adults. We aimed to determine the effects of AA administration on hemostatic responses to MS in overweight/obese men. Fourteen overweight/obesity men (27 ± 7 years; BMI 29.7 ± 2.6 kg m-2) performed the Stroop color-word stress task for 5 min after non-simultaneous infusion of placebo (PL, 0.9% NaCl) and AA (3 g). Blood was collected at baseline, during MS, and 60 min after MS to

measure:

activated partial thromboplastin time, prothrombin time, and fibrinogen concentration, by coagulometer; platelet-derived microvesicles (PMV, mv/µL), by flow cytometry; nitrite (µM), by chemiluminescence. In PL session, MS led to decreases in PTs (stress, p = 0.03; 60 min, p < 0.001), PT-INR (stress, p < 0.001; 60 min, p < 0.01), aPTTs (60 min, p = 0.03), aPTT ratio (60 min, p = 0.04) and fibrinogen (60 min, p = 0.04), while increased PT activity (60 min, p = 0.01) when compared to baseline. Furthermore, AA increased PTs (60 min, p < 0.001), PT-INR (60 min, p = 0.03) and decreased PT activity (60 min, p < 0.001) and fibrinogen (stress, p = 0.04) when compared to PL. Nitrite was increased in response to stress during AA session (p < 0.001 vs PL). There was no difference in PMV. Ascorbic acid prevented the impaired hemostatic profile and improved nitrite response to stress in the overweight and obese adults.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemostáticos / Trombofilia Tipo de estudo: Clinical_trials Limite: Adult / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemostáticos / Trombofilia Tipo de estudo: Clinical_trials Limite: Adult / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article