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Small ischemic lesions accompanying intracerebral hemorrhage: The underlying influence of old lacunes and polyunsaturated fatty acids.
Okumura, Motohiro; Sato, Takeo; Takahashi, Junichiro; Kokubu, Tatsushi; Nakada, Ryoji; Kitagawa, Tomomichi; Tanabe, Maki; Takatsu, Hiroki; Onda, Asako; Komatsu, Teppei; Sakuta, Kenichi; Sakai, Kenichiro; Umehara, Tadashi; Mitsumura, Hidetaka; Iguchi, Yasuyuki.
Afiliação
  • Okumura M; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Sato T; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan. Electronic address: takeo.sato.821@gmail.com.
  • Takahashi J; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Kokubu T; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Nakada R; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Kitagawa T; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Tanabe M; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Takatsu H; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Onda A; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Komatsu T; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Sakuta K; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Sakai K; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Umehara T; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Mitsumura H; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
  • Iguchi Y; Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
Nutr Metab Cardiovasc Dis ; 34(5): 1157-1165, 2024 May.
Article em En | MEDLINE | ID: mdl-38331645
ABSTRACT
BACKGROUND AND

AIMS:

Small ischemic lesions (SILs) accompanying intracerebral hemorrhage (ICH) might be induced by small-vessel vulnerability and hypercoagulation. Some polyunsaturated fatty acids (PUFAs) have been associated with hypercoagulation in cardiovascular diseases. Our aim here is to determine how pre-existing small-vessel disease (SVD) and PUFAs may affect SILs. METHODS AND

RESULTS:

We screened consecutive ICH patients (October 2012-December 2021) meeting two inclusion criteria (1) the patients were hospitalized for acute ICH and were undergoing magnetic resonance imaging and (2) the patients' PUFA measurements were available. After excluding patients with isolated intraventricular hemorrhage, we evaluated whether three SVD markers (white matter hyperintensities, old lacunes, cerebral microbleeds) and PUFAs might be associated with the development of SILs. We selected 319 participants from 377 screened consecutive ICH patients (median age = 64, males = 207 [65 %]). Of the 319 patients, 45 patients (14 %) developed SILs. In a multivariable logistic regression analysis, the factors associated with SILs were old lacunes (OR 3.255, 95 % CI 1.101-9.622, p = 0.033) and DHA/AA ratio (OR 0.180, 95 % CI 0.046-0.704, p = 0.013). Furthermore, in our multivariable analysis using DHA/AA ratio tertiles with and without SILs, we observed a linear trend between SILs and the Higher Tertile of the DHA/AA ratio (DHA/AA ratio Mid-Tertile OR 1.330, 95%CI 0.557-3.177, p = 0.521, and DHA/AA ratio Lower Tertile OR 2.632, 95%CI 1.124-6.162, p = 0.026).

CONCLUSION:

The presence of old lacunes and lower DHA/AA ratios might be associated with SILs accompanying ICH.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças de Pequenos Vasos Cerebrais Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças de Pequenos Vasos Cerebrais Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article