Potential clinical significance of ALDH3B1 in auxiliary diagnosis of gastric cancer.
Biomark Med
; 18(1): 15-23, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38334412
ABSTRACT
Objective:
This research aimed to explore a diagnostic method based on serum ALDH3B1 and to evaluate the clinical diagnostic efficacy in gastric cancer (GC) by comparing it with the traditional GC diagnostic method, the carcinoembryonic protein (CEA) assay.Methods:
Serum samples were collected from 70 healthy volunteers and various patients (GC 76, benign gastric lesions 20, postoperative 37, recurrence 56). The diagnostic efficacy of serum ALDH3B1, CEA and the co-diagnosis were evaluated by receiver operating characteristic curve. ALDH3B1 protein levels were evaluated by western blot.Results:
The co-diagnosis of ALDH3B1 and CEA had the highest diagnostic efficacy (area under the curve = 0.841).Conclusion:
Serum ALDH3B1 may be used as an auxiliary diagnostic biomarker for GC, and its co-diagnosis with CEA can improve diagnostic efficacy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Antígeno Carcinoembrionário
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article