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Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study.
Georgiadis, Foivos; Larivière, Sara; Glahn, David; Hong, L Elliot; Kochunov, Peter; Mowry, Bryan; Loughland, Carmel; Pantelis, Christos; Henskens, Frans A; Green, Melissa J; Cairns, Murray J; Michie, Patricia T; Rasser, Paul E; Catts, Stanley; Tooney, Paul; Scott, Rodney J; Schall, Ulrich; Carr, Vaughan; Quidé, Yann; Krug, Axel; Stein, Frederike; Nenadic, Igor; Brosch, Katharina; Kircher, Tilo; Gur, Raquel; Gur, Ruben; Satterthwaite, Theodore D; Karuk, Andriana; Pomarol-Clotet, Edith; Radua, Joaquim; Fuentes-Claramonte, Paola; Salvador, Raymond; Spalletta, Gianfranco; Voineskos, Aristotle; Sim, Kang; Crespo-Facorro, Benedicto; Tordesillas Gutiérrez, Diana; Ehrlich, Stefan; Crossley, Nicolas; Grotegerd, Dominik; Repple, Jonathan; Lencer, Rebekka; Dannlowski, Udo; Calhoun, Vince; Rootes-Murdy, Kelly; Demro, Caroline; Ramsay, Ian S; Sponheim, Scott R; Schmidt, Andre; Borgwardt, Stefan.
Afiliação
  • Georgiadis F; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital University of Zurich, Zurich, Switzerland. foivos.georgiadis@uzh.ch.
  • Larivière S; McGill University, Montreal Neurological Institute, Montreal, QC, Canada.
  • Glahn D; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
  • Hong LE; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, US.
  • Kochunov P; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, US.
  • Mowry B; Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.
  • Loughland C; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, USA.
  • Pantelis C; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Carlton South, VIC, Australia.
  • Henskens FA; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
  • Green MJ; School of Clinical Medicine, Discipline of Psychiatry and Mental Health, UNSW Sydney, Sydney, NSW, Australia.
  • Cairns MJ; School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
  • Michie PT; School of Psychological Sciences, University of Newcastle, Newcastle, NSW, Australia.
  • Rasser PE; School of Medicine and Public Health, College of Health, Medicine, and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia.
  • Catts S; Faculty of Medicine, University of Queensland, St Lucia, QLD, Australia.
  • Tooney P; School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
  • Scott RJ; Hunter Medical Research Institute, Newcastle, NSW, Australia.
  • Schall U; School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
  • Carr V; Hunter Medical Research Institute, Newcastle, NSW, Australia.
  • Quidé Y; School of Clinical Medicine, Discipline of Psychiatry, UNSW Sydney, Sydney, NSW, Australia.
  • Krug A; School of Clinical Medicine, Discipline of Psychiatry and Mental Health, UNSW Sydney, Sydney, NSW, Australia.
  • Stein F; University Hospital Bonn, Department of Psychiatry and Psychotherapy, Venusberg-Campus 1, 53127, Bonn, Germany.
  • Nenadic I; Department of Psychiatry, University of Marburg, Rudolf Bultmann Str. 8, 35039, Marburg, Germany.
  • Brosch K; Department. of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
  • Kircher T; Department of Psychiatry, University of Marburg, Rudolf Bultmann Str. 8, 35039, Marburg, Germany.
  • Gur R; Department of Psychiatry, University of Marburg, Rudolf Bultmann Str. 8, 35039, Marburg, Germany.
  • Gur R; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Satterthwaite TD; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Karuk A; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Pomarol-Clotet E; FIDMAG Germanes Hospitalàries Research Foundation & CIBERSAM, ISCIII, Barcelona, Spain.
  • Radua J; FIDMAG Germanes Hospitalàries Research Foundation & CIBERSAM, ISCIII, Barcelona, Spain.
  • Fuentes-Claramonte P; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Salvador R; FIDMAG Germanes Hospitalàries Research Foundation & CIBERSAM, ISCIII, Barcelona, Spain.
  • Spalletta G; FIDMAG Germanes Hospitalàries Research Foundation & CIBERSAM, ISCIII, Barcelona, Spain.
  • Voineskos A; Santa Lucia Foundation IRCCS, Santa Lucia, Rome, Italy.
  • Sim K; School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
  • Crespo-Facorro B; West Region, Institute of Mental Health, Singapore, Singapore.
  • Tordesillas Gutiérrez D; Hospital Universitario Virgen del Rocío, IBiS-CSIC, Universidad de Sevilla, Seville, Spain.
  • Ehrlich S; Department of Radiology, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain.
  • Crossley N; Division of Psychological & Social Medicine and Developmental Neurosciences, Technischen Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany.
  • Grotegerd D; Department of Psychiatry, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Repple J; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Lencer R; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Calhoun V; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Rootes-Murdy K; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA.
  • Demro C; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA.
  • Ramsay IS; University of Minnesota Department of Psychology, Minneapolis, MN, USA.
  • Sponheim SR; Minneapolis VA Health Care System, Minneapolis, MN, USA.
  • Schmidt A; University of Minnesota Department of Psychiatry & Behavioral Sciences, Minneapolis, MN, USA.
  • Borgwardt S; Minneapolis VA Health Care System, Minneapolis, MN, USA.
Mol Psychiatry ; 29(6): 1869-1881, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38336840
ABSTRACT
Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying network layout. We tested whether large-scale structural alterations in schizophrenia relate to normative structural and functional connectome architecture, and systematically evaluated robustness and generalizability of these network-level alterations. Leveraging anatomical MRI scans from 2439 adults with schizophrenia and 2867 healthy controls from 26 ENIGMA sites and normative data from the Human Connectome Project (n = 207), we evaluated structural alterations of schizophrenia against two network susceptibility models (i) hub vulnerability, which examines associations between regional network centrality and magnitude of disease-related alterations; (ii) epicenter mapping, which identifies regions whose typical connectivity profile most closely resembles the disease-related morphological alterations. To assess generalizability and specificity, we contextualized the influence of site, disease stages, and individual clinical factors and compared network associations of schizophrenia with that found in affective disorders. Our findings show schizophrenia-related cortical thinning is spatially associated with functional and structural hubs, suggesting that highly interconnected regions are more vulnerable to morphological alterations. Predominantly temporo-paralimbic and frontal regions emerged as epicenters with connectivity profiles linked to schizophrenia's alteration patterns. Findings were robust across sites, disease stages, and related to individual symptoms. Moreover, transdiagnostic comparisons revealed overlapping epicenters in schizophrenia and bipolar, but not major depressive disorder, suggestive of a pathophysiological continuity within the schizophrenia-bipolar-spectrum. In sum, cortical alterations over the course of schizophrenia robustly follow brain network architecture, emphasizing marked hub susceptibility and temporo-frontal epicenters at both the level of the group and the individual. Subtle variations of epicenters across disease stages suggest interacting pathological processes, while associations with patient-specific symptoms support additional inter-individual variability of hub vulnerability and epicenters in schizophrenia. Our work outlines potential pathways to better understand macroscale structural alterations, and inter- individual variability in schizophrenia.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Imageamento por Ressonância Magnética / Conectoma Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Imageamento por Ressonância Magnética / Conectoma Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article