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New phenylbutenoids and terpene glycosides from Ginkgo biloba leaves.
Sun, Zeshi; Lin, Shan; Wu, Zhi-Li; Dong, Hong-Yuan; Xu, Xi-Ke; Li, Hui-Liang; Wang, Jinxin.
Afiliação
  • Sun Z; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Lin S; State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
  • Wu ZL; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Dong HY; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Xu XK; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Li HL; School of Pharmacy, Second Military Medical University, Shanghai 200433, China. Electronic address: faranli@hotmail.com.
  • Wang J; School of Pharmacy, Second Military Medical University, Shanghai 200433, China. Electronic address: jxwang2013@126.com.
Chin J Nat Med ; 22(2): 161-170, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38342568
ABSTRACT
Our continued works on the chemical constituents of Ginkgo biloba (G. biloba) leaves has led to the isolation of two novel phenylbutenoids (1, 2), along with five previously unidentified terpene glycosides (3-7). Among them, compounds 1 and 2 represent unique (Z)-phenylbutenoids, 3-6 are megastigmane glycosides, and 7 is identified as a rare bilobanone glycoside (Fig. 1). This study marks the first reported isolation of phenylbutenoid and bilobanone glycoside from G. biloba. The chemical structures of these compounds were elucidated through extensive spectroscopic analysis, including HR-ESI-MS and various 1D and 2D NMR experiments. Furthermore, the absolute configurations of these molecules were determined using Mosher's method, ECD experiments, and Cu-Kα X-ray crystallographic analyses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicosídeos Cardíacos / Glicosídeos Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicosídeos Cardíacos / Glicosídeos Idioma: En Ano de publicação: 2024 Tipo de documento: Article