Efficacy and safety of platelet-rich plasma in the treatment of venous ulcers: A systematic review and meta-analysis of randomized controlled trials.
Int Wound J
; 21(2): e14736, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38361238
ABSTRACT
Considering the substantial impact of venous ulcers on quality of life and healthcare systems, this study evaluated the efficacy and safety of platelet-rich plasma (PRP) in comparison to conventional therapy. A systematic review of four databases identified 16 randomized clinical trials, including 20 study groups. PRP significantly enhanced complete ulcer healing, exhibiting an odds ratio (OR) of 5.06 (95% confidence interval [CI] 2.35-10.89), and increased the percentage of healed ulcer area by a mean difference of 47% (95% CI 32%-62%). Additionally, PRP shortened the time required for complete healing by an average of 3.25 months (95% CI -4.06 to -2.43). Although pain reduction was similar in both groups, PRP considerably decreased ulcer recurrence rates (OR = 0.16, 95% CI 0.05-0.50) without increasing the risks of infection or irritative dermatitis. These results suggest PRP as a viable, safe alternative for venous ulcer treatment, providing significant improvements in healing outcomes.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Úlcera Varicosa
/
Cicatrização
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Ensaios Clínicos Controlados Aleatórios como Assunto
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Plasma Rico em Plaquetas
Tipo de estudo:
Clinical_trials
/
Systematic_reviews
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article