Your browser doesn't support javascript.
loading
Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis.
Nao, Naganori; Okagawa, Tomohiro; Nojiri, Naomi; Konnai, Satoru; Shimakura, Honami; Tominaga, Misono; Yoshida-Furihata, Hazuka; Nishiyama, Eri; Matsudaira, Takahiro; Maekawa, Naoya; Murata, Shiro; Muramatsu, Masamichi; Ohashi, Kazuhiko; Saito, Masumichi.
Afiliação
  • Nao N; Division of International Research Promotion, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Okagawa T; One Health Research Center, Hokkaido University, Sapporo, Japan.
  • Nojiri N; Institute for Vaccine Research and Development (IVReD), Hokkaido University, Sapporo, Japan.
  • Konnai S; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
  • Shimakura H; Center for Emergency Preparedness and Response, National Institute of Infectious Diseases, Tokyo, Japan.
  • Tominaga M; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan. konnai@vetmed.hokudai.ac.jp.
  • Yoshida-Furihata H; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan. konnai@vetmed.hokudai.ac.jp.
  • Nishiyama E; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
  • Matsudaira T; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
  • Maekawa N; Center for Emergency Preparedness and Response, National Institute of Infectious Diseases, Tokyo, Japan.
  • Murata S; Biotechnological Research Support Division, FASMAC Co., Ltd, Atsugi, Japan.
  • Muramatsu M; Biotechnological Research Support Division, FASMAC Co., Ltd, Atsugi, Japan.
  • Ohashi K; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
  • Saito M; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Arch Virol ; 169(3): 47, 2024 Feb 16.
Article em En | MEDLINE | ID: mdl-38366081
ABSTRACT
Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3 chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from a cow with EBL. The chimeric provirus harbored a spliced SMAD3 sequence composed of exons 3-9, encoding the short isoform protein, and the BLV-SMAD3 chimeric transcript was detectable in cattle with EBL. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucose Enzoótica Bovina / Vírus da Leucemia Bovina Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucose Enzoótica Bovina / Vírus da Leucemia Bovina Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article