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Optimization of the Zhou Tian Formula extraction technology based on AHP-CRITIC method and analysis of transfer efficiency of key components based on HPLC fingerprinting.
Ma, Yi-Feng; Feng, Yang; Yao, Li-Li; Feng, Pei-Shi; Zhou, Wei-Kang; Fang, Le-Xuan; Tao, Yi; Wang, Ping.
Afiliação
  • Ma YF; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
  • Feng Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
  • Yao LL; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
  • Feng PS; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
  • Zhou WK; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
  • Fang LX; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
  • Tao Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
  • Wang P; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
Phytochem Anal ; 35(4): 873-888, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38366710
ABSTRACT

INTRODUCTION:

Zhou Tian Formula (ZTF) is an antidepressant traditional Chinese medicine utilized widely in clinical settings for the treatment of patients with depression. However, shortcomings persist in its extraction technology and quality control.

OBJECTIVE:

This study aimed to propose a methodology for ZTF extraction technology based on the analytic hierarchy process (AHP)-criteria importance through intercriteria correlation (CRITIC) method and to establish a quality control framework for the efficient transfer of index components.

METHOD:

Firstly, we analyzed the chemical components of ZTF and determined the optimal extraction technology. Secondly, we calculated the transfer efficiency of the index components during the conversion of water decoction to extract powder and subsequently to granules. Thirdly, we established HPLC fingerprints for 15 batches of ZTF water decoction, extract powder, and granules. We employed SIMCA software to analyze the chemicals responsible for variations in quality among different batches of ZTF granules.

RESULTS:

We determined the optimal extraction process. The average transfer efficiency of ferulic acid, puerarin, mirificin, isoferulic acid, and calycosin during the conversion of water decoction to extract powder and subsequently to granules exceeded 41%. The HPLC fingerprints of ZTF exhibited a similarity exceeding 0.890. Variable importance in projection values indicated that calycosin, ferulic acid, and puerarin were the primary contributors to quality variations.

CONCLUSIONS:

The AHP-CRITIC method, coupled with an orthogonal array design, could be used for exploring extraction technology. In addition, the rules governing the transfer of index components from water decoction to extract powder, and subsequently to granules, could be applied for the evaluation and quality assessment of ZTF.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas Idioma: En Ano de publicação: 2024 Tipo de documento: Article