Bacterial pseudaminic acid binding to Siglec-10 induces a macrophage interleukin-10 response and suppresses phagocytosis.
Chem Commun (Camb)
; 60(21): 2930-2933, 2024 Mar 07.
Article
em En
| MEDLINE
| ID: mdl-38372418
ABSTRACT
Pseudaminic acid (Pse) on pathogenic bacteria exopolysaccharide engages with the sialic acid-binding immunoglobulin-type lectin (Siglec)-10 receptor on macrophages via the critical 7-N-acetyl group. This binding stimulates macrophages to secrete interleukin 10 that suppresses phagocytosis against bacteria, but can be reverted by blocking Pse-Siglec-10 interaction with Pse-binding protein as a promising therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Açúcares Ácidos
/
Interleucina-10
/
Macrófagos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article