High and low pitch sound stimuli effects on heart-brain coupling.

ABSTRACT

This study aimed to explore the influence of sound stimulation on heart rate and the potential coupling between cardiac and cerebral activities. Thirty-one participants underwent exposure to periods of silence and two distinct continuous, non-repetitive pure tone stimuli low pitch (110 Hz) and high pitch (880 Hz). Electroencephalography (EEG) data from electrodes F3, F4, F7, F8, Fp1, Fp2, T3, T4, T5, and T6 were recorded, along with R-R interval data for heart rate. Heart-brain connectivity was assessed using wavelet coherence between heart rate variability (HRV) and EEG envelopes (EEGE). Heart rates were significantly lower during high and low-pitch sound periods than in silence (p < 0.002). HRV-EEGE coherence was significantly lower during high-pitch intervals than silence and low-pitch sound intervals (p < 0.048), specifically between the EEG Beta band and the low-frequency HRV range. These results imply a differential involvement of the frontal and temporal brain regions in response to varying auditory stimuli. Our findings highlight the essential nature of discerning the complex interrelations between sound frequencies and their implications for heart-brain connectivity. Such insights could have ramifications for conditions like seizures and sleep disturbances. A deeper exploration is warranted to decipher specific sound stimuli's potential advantages or drawbacks in diverse clinical scenarios.