Melanocortin-1 receptor (MC1R): a review for dermatologists.
Ital J Dermatol Venerol
; 159(3): 285-293, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38376504
ABSTRACT
Melanocortin-1 receptor (MC1R) and its variants have a pivotal role in melanin synthesis. However, MC1R has been associated to non-pigmentary pathways related to DNA-repair activities and inflammation. The aim of this review is to provide an up-to-date overview about the role of MC1R in the skin. Specifically, after summarizing the current knowledge about MC1R structure and polymorphisms, we report data concerning the correlation between MC1R, phenotypic traits, skin aging, other diseases and skin cancers and their risk assessment through genetic testing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Receptor Tipo 1 de Melanocortina
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article