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Preparation of hyaluronic acid-loaded liquid-core hydrogel beads with acceptable mechanical properties and thermal stability.
Li, Hang; Zhang, Qinyi; Chen, Ling; Wang, Yongzhi; Ai, Zheng; Zhang, Tianmeng; Liu, Fei; Zhong, Fang.
Afiliação
  • Li H; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.
  • Zhang Q; Science Center for Future Foods, Jiangnan University, Wuxi, China.
  • Chen L; School of Food Science and Technology, Jiangnan University, Wuxi, China.
  • Wang Y; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, China.
  • Ai Z; Jiaxing Institute of Future Food, Jiaxing, China.
  • Zhang T; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.
  • Liu F; Science Center for Future Foods, Jiangnan University, Wuxi, China.
  • Zhong F; School of Food Science and Technology, Jiangnan University, Wuxi, China.
J Sci Food Agric ; 104(10): 5834-5845, 2024 Aug 15.
Article em En | MEDLINE | ID: mdl-38380967
ABSTRACT

BACKGROUND:

Hyaluronic acid liquid-core hydrogel beads (HA-LHB) is a good way for oral intake of HA. However, HA may affect the reaction-diffusion of sodium alginate (SA) and Ca2+ leading to poor mechanical properties, since HA is a polyanionic electrolyte having electrostatic effect and a certain spatial site-blocking effect.

RESULTS:

The mechanical properties of HA-LHB were modified from bathing solution, core solution and secondary calcium bath time. The mechanical properties varied with the SA structure and concentration in bathing solution, where SA with high G (guluronic acid) segment compounded with SA with high M (mannuronic acid) segment at a mass ratio of 73 with a 11 g kg-1 concentration showed the best mechanical properties. The secondary calcium bath can greatly improve the mechanical properties due to the tight network formed by bidirectional crosslinking, and 15 min reaction reached the plateau if Ca2+ is sufficient. And the mechanical properties were positively correlated with calcium lactate concentration only at <70 g kg-1 in core solution, but the diffusion of Ca2+ was hindered by the tight gel network at higher concentrations. Moreover, the mechanical properties can be maintained during heat treatment, due to the rearrangement of alginate network structure.

CONCLUSION:

Our results suggested that the problem of poor mechanical properties of LHB in the presence of high HA concentration can be avoided by process control, which may broaden the development of HA and popping boba market. © 2024 Society of Chemical Industry.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hidrogéis / Alginatos / Temperatura Alta / Ácido Hialurônico Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hidrogéis / Alginatos / Temperatura Alta / Ácido Hialurônico Idioma: En Ano de publicação: 2024 Tipo de documento: Article