ADAM33's Role in Asthma Pathogenesis: An Overview.
Int J Mol Sci
; 25(4)2024 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-38396994
ABSTRACT
Asthma is a complex chronic respiratory disease characterized by airway hyperresponsiveness, inflammation, and obstruction. Many genes have been identified as associated with asthma but none with such substantial significance as the ADAM33 gene due to its role in airway remodeling and bronchial hyperresponsiveness. This review summarizes the current knowledge on the genetic and functional aspects of ADAM33 in asthma pathogenesis. We highlight its genetic variants associated with asthma susceptibility and severity, as well as the functional effects of ADAM33 on airway remodeling, smooth muscle cell proliferation, and its interplay with environmental factors. Additionally, we discuss the potential clinical implications of ADAM33 as a therapeutic target for asthma management.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Hiper-Reatividade Brônquica
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article