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Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics.
Liu, Gary W; Pickett, Matthew J; Kuosmanen, Johannes L P; Ishida, Keiko; Madani, Wiam A M; White, Georgia N; Jenkins, Joshua; Park, Sanghyun; Feig, Vivian R; Jimenez, Miguel; Karavasili, Christina; Lal, Nikhil B; Murphy, Matt; Lopes, Aaron; Morimoto, Joshua; Fitzgerald, Nina; Cheah, Jaime H; Soule, Christian K; Fabian, Niora; Hayward, Alison; Langer, Robert; Traverso, Giovanni.
Afiliação
  • Liu GW; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Pickett MJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Kuosmanen JLP; Department of Chemistry, Yale University, New Haven, CT, USA.
  • Ishida K; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Madani WAM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • White GN; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Jenkins J; Fractyl Health, Inc., Lexington, MA, USA.
  • Park S; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Feig VR; Weill Cornell Medical College, New York City, NY, USA.
  • Jimenez M; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Karavasili C; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Lal NB; Ross University School of Veterinary Medicine, Basseterre, St. Kitts and Nevis.
  • Murphy M; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Lopes A; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Morimoto J; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Fitzgerald N; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Cheah JH; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Soule CK; Stanford University, Stanford, CA, USA.
  • Fabian N; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Hayward A; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Langer R; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Traverso G; Boston University, Boston, MA, USA.
Nat Mater ; 2024 Feb 27.
Article em En | MEDLINE | ID: mdl-38413810
ABSTRACT
Pills are a cornerstone of medicine but can be challenging to swallow. While liquid formulations are easier to ingest, they lack the capacity to localize therapeutics with excipients nor act as controlled release devices. Here we describe drug formulations based on liquid in situ-forming tough (LIFT) hydrogels that bridge the advantages of solid and liquid dosage forms. LIFT hydrogels form directly in the stomach through sequential ingestion of a crosslinker solution of calcium and dithiol crosslinkers, followed by a drug-containing polymer solution of alginate and four-arm poly(ethylene glycol)-maleimide. We show that LIFT hydrogels robustly form in the stomachs of live rats and pigs, and are mechanically tough, biocompatible and safely cleared after 24 h. LIFT hydrogels deliver a total drug dose comparable to unencapsulated drug in a controlled manner, and protect encapsulated therapeutic enzymes and bacteria from gastric acid-mediated deactivation. Overall, LIFT hydrogels may expand access to advanced therapeutics for patients with difficulty swallowing.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article