Carrageenan derived polyelectrolyte complexes material: An effective bifunctional for electrochemical sensing of sulfamethazine and antibacterial activity.

ABSTRACT

Biopolymer-derived polyelectrolyte complexes (PECs) are a class of materials that have emerged as promising candidates for developing advanced electrochemical sensors due to their tunable properties, biocompatibility, cost-effective production, and high surface area. PECs are formed by combining positively and negatively charged polymers, resulting in a network with intriguing properties that can be tailored for specific sensing applications. The resultant PECs-based nanocomposites were used to modify the glassy carbon electrode (GCE) to detect the sulfamethazine (SFZ) antibiotic drug. In addition, electrochemical studies using electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV) are used to evaluate the SFZ detection ability. Similarly, various microscopic and spectroscopic studies investigated the nano composite's structural features and morphological behavior. The κ-CGN/P(Am-co-DMDAAc)-GO modified GCE demonstrated excellent detection ability of SFZ with the nano molar range and without interference with similar structural components. Furthermore, the newly fabricated electrode κ-CGN/P(Am-co-DMDAAc)-GO was derived from naturally available materials, water-soluble, low cost, biocompatible, exhibits good conductivity, and excellent catalytic properties. Finally, κ-CGN/P(Am-co-DMDAAc)-GO- modified GCE has versatile, practical applications for detecting SFZ in real-time samples and determining the efficacy of an antibacterial activity.