Identification of plb1 mutation that extends longevity via activating Sty1 MAPK in Schizosaccharomyces pombe.
Mol Genet Genomics
; 299(1): 20, 2024 Feb 29.
Article
em En
| MEDLINE
| ID: mdl-38424265
ABSTRACT
To understand the lifespan of higher organisms, including humans, it is important to understand lifespan at the cellular level as a prerequisite. So, fission yeast is a good model organism for the study of lifespan. To identify the novel factors involved in longevity, we are conducting a large-scale screening of long-lived mutant strains that extend chronological lifespan (cell survival in the stationary phase) using fission yeast. One of the newly acquired long-lived mutant strains (No.98 mutant) was selected for analysis and found that the long-lived phenotype was due to a missense mutation (92Phe â Ile) in the plb1+ gene. plb1+ gene in fission yeast is a nonessential gene encoding a homolog of phospholipase B, but its functions under normal growth conditions, as well as phospholipase B activity, remain unresolved. Our analysis of the No.98 mutant revealed that the plb1 mutation reduces the integrity of the cellular membrane and cell wall and activates Sty1 via phosphorylation.
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01-internacional
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MEDLINE
Assunto principal:
Schizosaccharomyces
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Proteínas Quinases Ativadas por Mitógeno
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Proteínas de Schizosaccharomyces pombe
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Lisofosfolipase
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article