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Epigenome-wide association study of long-term psychosocial stress in older adults.
Opsasnick, Lauren A; Zhao, Wei; Schmitz, Lauren L; Ratliff, Scott M; Faul, Jessica D; Zhou, Xiang; Needham, Belinda L; Smith, Jennifer A.
Afiliação
  • Opsasnick LA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Schmitz LL; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
  • Ratliff SM; Robert M. La Follette School of Public Affairs, University of Wisconsin-Madison, Madison, WI, USA.
  • Faul JD; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Zhou X; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
  • Needham BL; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Epigenetics ; 19(1): 2323907, 2024 Dec.
Article em En | MEDLINE | ID: mdl-38431869
ABSTRACT
Long-term psychosocial stress is strongly associated with negative physical and mental health outcomes, as well as adverse health behaviours; however, little is known about the role that stress plays on the epigenome. One proposed mechanism by which stress affects DNA methylation is through health behaviours. We conducted an epigenome-wide association study (EWAS) of cumulative psychosocial stress (n = 2,689) from the Health and Retirement Study (mean age = 70.4 years), assessing DNA methylation (Illumina Infinium HumanMethylationEPIC Beadchip) at 789,656 CpG sites. For identified CpG sites, we conducted a formal mediation analysis to examine whether smoking, alcohol use, physical activity, and body mass index (BMI) mediate the relationship between stress and DNA methylation. Nine CpG sites were associated with psychosocial stress (all p < 9E-07; FDR q < 0.10). Additionally, health behaviours and/or BMI mediated 9.4% to 21.8% of the relationship between stress and methylation at eight of the nine CpGs. Several of the identified CpGs were in or near genes associated with cardiometabolic traits, psychosocial disorders, inflammation, and smoking. These findings support our hypothesis that psychosocial stress is associated with DNA methylation across the epigenome. Furthermore, specific health behaviours mediate only a modest percentage of this relationship, providing evidence that other mechanisms may link stress and DNA methylation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metilação de DNA / Epigenoma Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metilação de DNA / Epigenoma Idioma: En Ano de publicação: 2024 Tipo de documento: Article