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Scabies: Immunopathogenesis and pathological changes.
Sharaf, Mahmoud S.
Afiliação
  • Sharaf MS; Parasitology Department, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt. mahmoud.sharaf@med.tanta.edu.eg.
Parasitol Res ; 123(3): 149, 2024 Mar 04.
Article em En | MEDLINE | ID: mdl-38433167
ABSTRACT
Scabies is an itchy skin disease caused by the burrowing mite Sarcoptes scabiei. During their lifespan, the female mites invade the stratum corneum and create tunnels, in which they reside, move, feed, deposit fecal pellets, and lay eggs. Recently, scabies was included in the World Health Organization roadmap for neglected tropical diseases 2021-2030. This review attempts to summarize our knowledge about the mite's biology and the disease pathogenesis, pathological changes, and complications. Generally, the host-parasite interaction in scabies is highly complex and involves different mechanisms, some of which are yet largely unknown. Elucidation of the nature of such interaction as well as the underlying mechanisms could allow a better understanding of the mite's biology and the development of novel diagnostic and therapeutic options for scabies control programs. Moreover, identification of the molecular basis of such interaction could unveil novel targets for acaricidal agents and vaccines.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escabiose / Acaricidas Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escabiose / Acaricidas Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article