New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292.
J Antibiot (Tokyo)
; 77(5): 272-277, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38438501
ABSTRACT
Two new antimalarial compounds, named prenylpyridones A (1) and B (2), were discovered from the actinomycete cultured material of Streptomyces sp. RBL-0292 isolated from the soil on Hamahiga Island in Okinawa prefecture. The structures of 1 and 2 were elucidated as new iromycin analogs having α-pyridone ring by MS and NMR analyses. Compounds 1 and 2 showed moderate in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC50 values ranging from 80.7 to 106.7 µM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Streptomyces
/
Antimaláricos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article