The influence of synaptic plasticity on critical coupling estimates for neural populations.

ABSTRACT

The presence or absence of synaptic plasticity can dramatically influence the collective behavior of populations of coupled neurons. In this work, we consider spike-timing dependent plasticity (STDP) and its resulting influence on phase cohesion in computational models of heterogeneous populations of conductance-based neurons. STDP allows for the influence of individual synapses to change over time, strengthening or weakening depending on the relative timing of the relevant action potentials. Using phase reduction techniques, we derive an upper bound on the critical coupling strength required to retain phase cohesion for a network of synaptically coupled, heterogeneous neurons with STDP. We find that including STDP can significantly alter phase cohesion as compared to a network with static synaptic connections. Analytical results are validated numerically. Our analysis highlights the importance of the relative ordering of action potentials emitted in a population of tonically firing neurons and demonstrates that order switching can degrade the synchronizing influence of coupling when STDP is considered.